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Best Chicken Marsala Recipe on Earth

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Kids serving up chicken marsala

Why is Glycine in a Chicken Marsala Recipe so Healthy?

Cooking a loving meal for my family, packed with healthy nutrients, makes me feel really good. In the case of Chicken Marsala, there is a long list of added nutritional benefits from the amino acid, glycine. Focusing on this amino acid in your diet is not difficult. But it is mostly available in high-protein foods including meat, fish, eggs, and legumes. In the case of Chicken Marsala, both the chicken and the beef broth are key contributors to your glycine consumption.

Why is glycine so wonderful? It is an important component of essential biological molecules, a key substance in many metabolic reactions, the main inhibitory neurotransmitter in the spinal cord and brain stem, and an anti-inflammatory, immune-modulating substance. To make Chicken Marsala even healthier, enjoy making it with friends and family!

Did you know Chicken Marsala REcipe can be an Anti-Inflammatory Meal?

Over 15 years ago I received the basic recipe for this dish from one of my best friends. At the time, we had only a minimal concept of the health benefits. In addition, I had no idea where she found the recipe, but over the years I have learned to customize it to be gluten-free and better tasting than ever. Just substitute the flour from the recipe below with 1:1 gluten-free flour, and use gluten-free noodles. My favorite gluten-free brand is Bobs Red Mill. Above all else, Chicken Marsala is the perfect Italian comfort food. Having glycine as a component is a great benefit.

Many of you know I am allergic to mushrooms, but not severely, therefore I avoid eating the mushrooms in this recipe and leave those to the rest of my family. I highly recommend using organic and/or non-GMO ingredients as well.

List of the Top Benefits of Glycine

Glycine is very effective in improving overall health and supports well-being. Although glycine is produced in the body, there are overwhelming reports supporting the role of supplementary glycine in treating metabolic disorders in patients with cardiovascular diseases, several inflammatory diseases, obesity, cancers, and diabetes.

Glycine also has the property to enhance the quality of sleep and neurological functions. Some benefits of glycine may include:

  • Reduced inflammation in arthritis including rheumatoid 
  • Protection for gastrointestinal health
  • Aiding in digestion
  • Improved vascular health
  • Assisting as a central nervous system neurotransmitter
  • Acting as aid in treating cardiovascular disease
  • Improving sleep quality
  • Fighting against liver damage caused by alcohol abuse
  • Strengthening bones and joints


DISCLAIMER: Recipes and information shared are not intended to treat, cure or prevent any disease.

Chicken Marsala dinner with salad



  • Chicken Marsala Ingredients1 ½ Lbs. Boneless Skinless Chicken Breasts (pound out thin)
  • Salt and Pepper to taste
  • ½ Cup Flour (Substitute with Gluten Free Flour)
  • 2 Tbsp Oil (Extra Virgin Olive Oil is best)
  • ½ Lb. Sliced Mushrooms
  • 1 small onion, ground (a.k.a. chopped into smithereens)
  • ½ Cup Sweet Marsala Wine
  • ½ Cup Beef Broth
  • 2 Tbsp Butter (or substitute olive oil)


  1. Season chicken with salt and pepper to taste; coat with flour.
  2. Melt 2 Tbsp Butter and 2 Tbsp Oil in a large skillet; brown 3 to 4 minutes on each side.
  3. Remove chicken.
  4. Add mushrooms, onions, wine and ¼ cup of broth to skillet. Deglaze pan by heating to boiling; boil 1 to 2 minutes, scraping bottom to remove brown particles.
  5. Return chicken to skillet. Heat to boiling. Cover, reduce heat and simmer about 20 minutes. Baste meat twice with liquid.
  6. Place chicken on a warm covered platter in a low oven. Add remaining ¼ cup beef broth to skillet.  Heat to boiling and reduce by boiling and stirring until liquid is of syrup consistency. Stir in 2 Tbsp butter until melted.
  7. Pour sauce over chicken and serve.

 Special serving idea:

Add gluten-free pasta on the side, double the sauce and mushroom ingredients, drizzle the extra sauce over the pasta, and add a little fresh parmesan sprinkled over the top. For an anti-inflammatory alternative use gluten-free pasta.

Also – I recommend using real Marsala wine. There is no glycine benefit, it just tastes delicious. Although it may be hard to find in your grocery store, you can try going to a more specialized beverage supplier such as a liquor store or outlet. Alternatively, below is a great recipe for a non-alcoholic substitute to Marsala wine. 

Try a Non-Alcoholic Marsala Substitute

Although most of the alcohol evaporates during cooking, some people prefer to cook without using Marsala due to its alcohol content. Further, according to the Reluctant Gourmet, you can use this non-alcoholic substitute:

  • ¼ cup of white grape juice
  • 1 tablespoon vanilla extract
  • 2 tablespoons of sherry vinegar
Chicken Marsala sauce
Chicken Marsala simmering

Estimated Meal Cost: My guesstimate is around $10.00-$15.00 depending on the quality of Marsala wine that you choose. Additionally, this recipe is not calorie conscious but IS filled with delicious tastiness and has health benefits abound!

A lower-cost alternative to gaining a glycine rich meal, is this Easy Broth Recipe.



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  1. So glad to get this recipe, and can’t wait to try it! Thank you for sharing!

    It’s so nice to have “The Best Chicken Marsala Recipe on Earth” which saves time floundering around and wasting time on inferior recipes…if only the remainder of life’s decisions could be so easy?

  2. The sun hasn’t even risen here and I am drooling already! Thank you for posting your recipe. Who doesn’t love chicken Marsala, I mean who CAN’T love it?! You should try making sandwiches with some of it. Gorgeous yummy sandwiches. A restaurant here in Portland used to make them…alas it is gone now and so are those dreamy sandwiches.

  3. Shawna, the only ingredient (sides the wine) that might not be available to most folks as organic or GMO free is the beef broth. I avoid Campbell’s products because I understand they may contain GMOs. I am addicted to Better Than Bouillon and they have organic bases. I am definitely going to make this and I think I will also add sliced green olives to it. I will share it on my blog as well. Thanks for yet another great recipe dear!

  4. Thank you for sharing your Chicken Marsala recipe. I can’t wait to try it! I met you last Spring when you visited Mahoney’s Garden Center in East Falmouth last Spring. I have thoroughly enjoyed your blog and Facebook posts especially the Apocalyptic Garden! Keep up the great inspirations!

  5. We are going to have this for tonight’s dinner. Thanks for the recipe. I want to try the pot roast and cauliflower soon as well.

  6. Shawna, I get my Marsala on the counter. Does it make a difference? And lately I’ve been adding a touch of balsamic vinegar to almost every thing.

  7. I’ve been told to refrigerate it after you open it, so I would ask a wine expert at the local wine shop. Perhaps they would have a better answer. 🙂

    Balsamic vinegar is delicious!


  8. Any substitute for the wine? I know that sounds ridiculous on a Chicken Marsala recipe, but I’m allergic to wine, and this looks SO YUMMY!

  9. Thanks! Sunday dinner tonite ! Off to the grocer for ingredients, nice green salad and a loaf of sourdough french bread I’m ready to go.

  10. So i tried this recipe but instead of a can of beef broth I used a can of Progresso french onion soup. AMAZEBALLS!!!!!!!!

  11. I don’t make this very often, although its sooo yummy! And I hate letting things go bad or to waste. If you buy Marsala you can freeze the leftover wine in ice cube trays for the next time you cook this dish! :))

  12. Im planning on making this tonight, but the person at the liquor store told me to get dry Marsala wine. Is this going to make a huge difference?

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